Immune checkpoint blockade (ICB) therapy is an effective strategy for activating anti-tumor immunity. To increase the response rate and enhance efficacy, ICB combination therapy which combined ICB inhibitor and other drugs has emerged.

ICBcomb is a database that provides a comprehensive expression resource and functional analysis for ICB combination therapy studies. It compares expression between groups of Drug vs. Control, ICB vs. Control, Combination vs. Control, Combination vs. ICB, and Combination vs. Drug. This is the first database on expression resources for ICB combination therapy, and we aim to provide useful data for studies related to ICB combination therapy.